array(1) { [0]=> object(AppBundle\Entity\geneTOpubmed)#307 (6) { ["id":"AppBundle\Entity\geneTOpubmed":private]=> int(4519) ["geneNihId":"AppBundle\Entity\geneTOpubmed":private]=> int(945) ["pubmedNihId":"AppBundle\Entity\geneTOpubmed":private]=> int(9465907) ["title":"AppBundle\Entity\geneTOpubmed":private]=> string(106) "Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta." ["urltitle":"AppBundle\Entity\geneTOpubmed":private]=> string(105) "molecular-cloning-of-a-novel-gene-similar-to-myeloid-antigen-cd33-and-its-specific-expression-in-placenta" ["content":"AppBundle\Entity\geneTOpubmed":private]=> string(11097) " 9465907 1998 03 04 2018 02 14
0301-0171 78 3-4 1997 Cytogenetics and cell genetics Cytogenet. Cell Genet. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. 295-300 We have isolated a novel gene that encodes a protein sharing significant similarity with myeloid antigen CD33. The complete cDNA contains an open reading frame of 1,326 nucleotides encoding 442 amino acids. The deduced amino acid sequence indicates that this molecule belongs to the immunoglobulin (Ig) superfamily and is likely to be a new member of the sialoadhesin sub-family. It is composed of three Ig-like domains; its high degree of similarity to CD33 (70% identity) in the first and second of these domains implies that the placenta-specific gene product is likely to be associated with cell-cell interaction. Northern-blot analysis revealed transcripts of four distinct sizes, 7.5 kb, 5.0 kb, 4.1 kb, and 2.0 kb, specifically in the placenta. Consequently, we termed this gene CD33L (CD33 antigen-like). An alternatively-spliced transcript encoding a 342-amino-acid peptide which lacked the transmembrane region and the cytoplasmic tail was also isolated. We mapped CD33L by fluorescence in situ hybridization (FISH) to human chromosome 19q13.3, where the CD33 gene is also located. Takei Y Y Laboratory of Molecular Medicine, University of Tokyo, Japan. Sasaki S S Fujiwara T T Takahashi E E Muto T T Nakamura Y Y eng GENBANK D86358 D86359 Journal Article Research Support, Non-U.S. Gov't
Switzerland Cytogenet Cell Genet 0367735 0301-0171 0 Antigens, CD 0 Antigens, Differentiation, Myelomonocytic 0 CD33 protein, human 0 Cell Adhesion Molecules 0 DNA, Complementary 0 RNA, Messenger 0 Sialic Acid Binding Ig-like Lectin 3 0 Sialoglycoproteins IM Alternative Splicing Antigens, CD genetics Antigens, Differentiation, Myelomonocytic genetics Base Sequence Blotting, Northern Cell Adhesion Molecules genetics Chromosome Mapping Chromosomes, Human, Pair 19 Cloning, Molecular DNA, Complementary Gene Expression Regulation, Developmental Humans In Situ Hybridization, Fluorescence Molecular Sequence Data Placenta physiology RNA, Messenger analysis Sequence Homology, Amino Acid Sialic Acid Binding Ig-like Lectin 3 Sialoglycoproteins genetics
1997 1 1 0 0 1998 2 18 0 1 1997 1 1 0 0 ppublish 9465907 10.1159/000134676
" } }