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Prothrombin Antibody (12)

prothrombin antibody (12)

Catalog: sc-136449 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

 Prothrombin Antibody (12)  Prothrombin Antibody (12)

recommended for detection of Prothrombin of human origin by WBIP

F2 gene: coagulation factor II, thrombin

PT, RPRGL2, THPH1

Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Organism: human (Homo sapiens)