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All about genes

F12: coagulation factor XII

HAE3, HAEX, HAF

Summary

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)

F12 related publications

F12 description

Anti-human tnfrsf25 Catalog: 101-M664 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

Gene Name TNFRSF25 Species Reactivity Human (Homo sapiens) Synonyms TNFRSF25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
Anti-human tweak Catalog: 102-P90G | Size: 100ug | Price: €348.2 Supplier: Reliatech antibodies

Gene Name TWEAK Species Reactivity Human (Homo sapiens) Synonyms TNFSF12; APO3L; DR3LG; TWEAK
Anti-human tnfsf12 Catalog: 101-M673 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

Gene Name TNFSF12 Species Reactivity Human (Homo sapiens) Synonyms TNFSF12; APO3L; DR3LG; TWEAK
Anti-human tnfsf13 Catalog: 101-M674 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

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Gene Name Dectin-1 Species Reactivity Mouse (Mus musculus) Synonyms Clec7a; BGR; beta-GR; Clecsf12
Aif antibody Catalog: APO-2301 | Size: 0.1 mg | Price: €589.54 Supplier: Zyagen

Alternative name AIF (Antibody to) Gene target AIF Short name AIF Antibody
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Old catalog number 36-614-469422 Storage temperature store cold Expiry date 1 y
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DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
Immunoglobulin g Catalog: SC09F120 | Size: R1:45ml×2 R2:15ml×2 | Price: €201.81 Supplier: Szybio Lambert

Volume of reagent in a kit 120ml Test field of this automate Special Protein Reagents Insruments of IVD used for this reagent for Hitachi (7170/917) series and Olympus AU (400/600/640/100/2700/5400) series and Abbott Aerost and Siemens Advia (1200/2400) series and Bayer 1650 ; B: Hitachi 7060/7150/902/911 and Abbott Aeroset (C8000/ C16000) and Shimadzu (CL7200/7300/8000) and Olympus AU800 and Tosshiba 120FR and Sysmex Chemix 180, H: Hitachi 7020/902, C: Beckman, F: Toshiba 40, W: Toshiba 120, D: Dimension ; N: Mindray 200 ; L: Mindray 300 ; M: Mindray 400, T: Dupont.
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DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
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Fam167a lentiviral vector (human) (ef1a) (plenti-giii-ef1a) Catalog: LV156077 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
Ttpal over-expression lysate reagent Catalog: GWB-5AFA1D | Size: 1 x 1 vial | Price: €555.92 Supplier: genways

Old catalog number 36-614-466457 Storage temperature store cold Expiry date 1 y
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Old catalog number 36-614-467619 Storage temperature store cold Expiry date 1 y
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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Ring finger protein 125 (rnf125) rabbit antibody to or anti-human polyclonal antibody Catalog: GWB-D1E368 | Size: 1 vial | Price: €778.05 Supplier: genways

Old catalog number 18-464-436751 Storage temperature store cold Expiry date 1 y
Fam158a lentiviral vector (human) (ef1a) (plenti-giii-ef1a) Catalog: LV155981 | Size: 1.0 µg DNA | Price: €387.23 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
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Old catalog number 25-787-278485 Storage temperature store cold Expiry date 1 y
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Long name DCAF12 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-DCAF12 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
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Long name RNF12 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated Also known as Anti-RNF12 PAb ALEXA FLUOR 594 Category Conjugated Primary Antibodies
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Old catalog number 36-614-470680 Storage temperature store cold Expiry date 1 y
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Long name C1orf125 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-C1orf125 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
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Alternative name 1 Osteocalcin, Mab anti-Bovine; Clone: 3H8H12D2A12F12 Alternative name 2 Osteocalcin, Mab antibody-Bovine; Clone: 3H8H12D2A12F12 Alternative name 3 Osteocalcin, Mab antibody-Bovine; Clone: 3H8H12D2A12F12
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Old catalog number 20-614-460820 Storage temperature store cold Expiry date 1 y
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Alternative name TCF12 short protein sequence Gene target TCF12 Peptide Technique peptide
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Long name C8orf12 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated Also known as Anti-C8orf12 PAb ALEXA FLUOR 555 Category Conjugated Primary Antibodies
C1orf129 lentiviral vector (human) (ubc) (plenti-giii-ubc) Catalog: LV795025 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
C10orf120 lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV795270 | Size: 1.0 µg DNA | Price: €3678.46 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
Heatr5a lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV179137 | Size: 1.0 µg DNA | Price: €387.23 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
uid :
2161

name :
F12

description :
coagulation factor XII

chromosome :
5

geneticsource :
genomic

maplocation :
5q35.3

otheraliases :
HAE3, HAEX, HAF

otherdesignations :
coagulation factor XII|Hageman factor|beta-factor XIIa part 1|beta-factor XIIa part 2|coagulation factor XIIa heavy chain|coagulation factor XIIa light chain

nomenclaturesymbol :
F12

nomenclaturename :
coagulation factor XII

nomenclaturestatus :
Official

geneweight :
23918

chrsort :
05

chrstart :
177402137

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000005.10
chrstart: 177409575
chrstop: 177402137
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000005.10
chrstart: 177409575
chrstop: 177402137
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018916.2
chrstart: 176269624
chrstop: 176262186
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000005.10
chrstart: 177416523
chrstop: 177402137
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018916.2
chrstart: 176269624
chrstop: 176262186
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000005.10
chrstart: 177409575
chrstop: 177402137
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018916.2
chrstart: 176269624
chrstop: 176262186
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018916.2
chrstart: 176269624
chrstop: 176262186
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018916.1
chrstart: 177060968
chrstop: 177053530
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000048.1
chrstart: 171664876
chrstop: 171672314
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000005.9
chrstart: 176836576
chrstop: 176829138
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000048.1
chrstart: 171664876
chrstop: 171672314
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000005.8
chrstart: 176769182
chrstop: 176761744
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000048.1
chrstart: 171664876
chrstop: 171672314
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000137.1
chrstart: 171757003
chrstop: 171749565