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JAM-A Antibody (43)

jam-a antibody (43)

Catalog: sc-135956 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

 JAM-A Antibody (43)

recommended for detection of JAM-A of human origin by WB and IP

F11R gene: F11 receptor

CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)