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Human ASXL3 CRISPR Knock Out 293 Cell Line

Human asxl3 crispr knock out 293 cell line Catalog: K0138852 | Size: 1x10^6 cells/1.0ml | Price: €6989.27 Supplier: ABM CrispR ASK
Cell line type: 293 NCBI number: NM_030632 Availability: Please contact us every day to check the availability and/or to request a quote. For larger or bulk quantities a discount may apply.

ASXL3 gene: additional sex combs like 3, transcriptional regulator

BRPS, KIAA1713

Summary

This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017]

Organism: human (Homo sapiens)