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All about genes

APP: amyloid beta precursor protein

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4

Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Organism: human (Homo sapiens)

APP description

Anti-human pappalysin-2 Catalog: 101-M600 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

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Gene Name Pappalysin-2 Species Reactivity Human (Homo sapiens) Synonyms PAPPA2; PAPPE; PLAC3; PAPP-A2
Anti-human trappin-2 Catalog: 101-M686 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

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Gene Name Trappin-2 Species Reactivity Human (Homo sapiens) Synonyms PI3; ESI; WAP3; SKALP; WFDC14; cementoin
Kappa light chain antibody (fitc conjugated) Catalog: GWB-20AC8E | Size: 1 x 1 vial | Price: €638.77 Supplier: genways

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Old catalog number 18-272-197294 Storage temperature store cold Expiry date 1 y
Polymerase (dna-directed) kappa (polk) goat antibody to or anti-human polyclonal (aa817-830) antibody Catalog: GWB-AA7808 | Size: 1 vial | Price: €722.82 Supplier: genways

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Old catalog number 18-464-436555 Storage temperature store cold Expiry date 1 y
Trappc4 antibody Catalog: GWB-MU549I | Size: 1 vial | Price: €625.56 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Kappa (free), clone: 2b7, mouse monoclonal antibody-human, frozen/paraffin Catalog: YM5001A-5 | Size: 5 ml | Price: €2151.65 Supplier: accurate-monoclonals

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Alternative name 1 Kappa (free), Clone: 2B7, Mab anti-Human, frozen/paraffin Alternative name 2 Kappa (free), Clone: 2B7, Mab antibody-Human, frozen/paraffin Alternative name 3 Kappa (free), Clone: 2B7, Mab antibody-Homo sapiens, frozen/paraffin
Goat antibody to or anti-human kappa ( chain specificity) Catalog: GWB-5640C1 | Size: 1 x 1 vial | Price: €480.28 Supplier: genways

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Old catalog number 25-787-278167 Storage temperature store cold Expiry date 1 y
Human nuclear factor-kappa b (nf-κb) elisa kit Catalog: AE31148HU | Size: 96 wells plate | Price: €972.57 Supplier: ab-elisa elisas

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Also known as Nuclear factor-kappa B (NF-κB) ELISA kit Species reactivity Human Recognised antigen Nuclear factor-kappa B
Impad1 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV189735 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

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DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Kappa 1 light chain rat -hrp, antibody Catalog: GWB-2BCB22 | Size: 1 x 1 vial | Price: €1679.78 Supplier: genways

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Old catalog number 20-251-401583 Storage temperature store cold Expiry date 1 y
Rat kappa 1b allotype, clone: lork1b-2, rat mouse monoclonal antibody-, biotin Catalog: YULLORK1b2-B-1 | Size: 1000ul | Price: €1016.99 Supplier: accurate-monoclonals

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Alternative name 1 Rat Kappa 1b allotype, Clone: LORK1b-2, Rat Mab anti-, Biotin Alternative name 2 Rat Kappa 1b allotype, Clone: LORK1b-2, Rat Mab antibody-, Biotin Alternative name 3 Rattus norvegicus Kappa 1b allotype, Clone: LORK1b-2, Rattus norvegicus Mab antibody-, Biotin
Kappa light chain antibody Catalog: GWB-FD3072 | Size: 1 vial | Price: €300.18 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Anti- nf-kappab-p105/p50 (phospho-ser337) antibody Catalog: GWB-55C010 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 0.05mg:165,0.1mg:242 Old catalog number 18-785-210309 Store store in freezer for long therm or fridge for short time storage
Nf kappa b inhibitor beta, mouse monoclonal antibody-; clone: 1b5 Catalog: YSRTMCA3293Z | Size: Ask | Price: Ask Supplier: accurate-monoclonals

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Alternative name 1 NF Kappa B Inhibitor Beta, Mab anti-; Clone: 1B5 Alternative name 2 NF Kappa B Inhibitor Beta, Mab antibody-; Clone: 1B5 Alternative name 3 NF Kappa B Inhibitor Beta, Mab antibody-; Clone: 1B5
Trappc2 over-expression lysate reagent Catalog: GWB-B7FA01 | Size: 1 vial | Price: €674.79 Supplier: genways

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Old catalog number 36-614-467954 Storage temperature store cold Expiry date 1 y
Rat kappa 1a allotype (weak x w/ rat igk1b), clone: mark-3, mouse monoclonal antibody- Catalog: YULMARK3-1 | Size: 1000ul | Price: €1210.31 Supplier: accurate-monoclonals

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Alternative name 1 Rat Kappa 1a allotype (weak x w/ Rat IgK1b), Clone: MARK-3, Mab anti- Alternative name 2 Rat Kappa 1a allotype (weak x w/ Rat IgK1b), Clone: MARK-3, Mab antibody- Alternative name 3 Rattus norvegicus Kappa 1a allotype (weak x w/ Rattus norvegicus IgK1b), Clone: MARK-3, Mab antibody-
Nfkb1 (ser337) antibody, alexa fluor 488 Catalog: bs-5512R-A488 | Size: 100ul | Price: €420.43 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name NFKB1 (Ser337) Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-NFKB1 Ser337 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
Pregnancy associated plasma protein a antibody Catalog: GWB-D92836 | Size: 1 vial | Price: €1610.14 Supplier: genways

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Old catalog number 20-511-242388 Storage temperature store cold Expiry date 1 y
Pappa2 antibody Catalog: GWB-MP195F | Size: 1 vial | Price: €625.56 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Goat f(ab')2 antibody to or anti-human kappa ( chain specificity) absorbed against mouse igs Catalog: GWB-F46EBF | Size: 1 vial | Price: €998.98 Supplier: genways

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Old catalog number 25-787-278184 Storage temperature store cold Expiry date 1 y
Pappa antibody, alexa fluor 594 Catalog: bs-6618R-A594 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name PAPPA Polyclonal Antibody, ALEXA FLUOR 594 Conjugated Also known as Anti-PAPPA PAb ALEXA FLUOR 594 Category Conjugated Primary Antibodies
Rat iga kappa, clone: ir22, myeloma Catalog: YULIR22a-1 | Size: 1000ul | Price: €1235.52 Supplier: accurate-monoclonals

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Alternative name 1 Rat IgA Kappa, Clone: IR22, Myeloma Alternative name 2 Rat IgA Kappa, Clone: IR22, Myeloma Alternative name 3 Rattus norvegicus IgA Kappa, Clone: IR22, Myeloma
Ercc1 antibody Catalog: GWB-A506AA | Size: 1 vial | Price: €798.47 Supplier: genways

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Old catalog number 20-614-460218 Storage temperature store cold Expiry date 1 y
Recombinant human glutathione s-transferase kappa 1 Catalog: GWB-D5E0F5 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 10ug:83,50ug:182,1000ug:2954 Old catalog number 10-663-46802 Store store in freezer for long therm or fridge for short time storage
Mouse kappa (min x ch,rb,gt,sh,hr,bab,hu igg, hu igm), clone: lomk2, rat mouse monoclonal antibody-, biotin Catalog: YULLOMK2-B05 | Size: 500ul | Price: €631.57 Supplier: accurate-monoclonals

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Alternative name 1 Mouse Kappa (min X Ch,Rb,Gt,Sh,Hr,Bab,Hu IgG, Hu IgM), Clone: LOMK2, Rat Mab anti-, Biotin Alternative name 2 Mouse Kappa (min X Ch,Rb,Gt,Sh,Hr,Bab,Hu IgG, Hu IgM), Clone: LOMK2, Rat Mab antibody-, Biotin Alternative name 3 Mus musculus Kappa (min X Ch,Rb,Gt,Sh,Hr,Bab,Hu IgG, Hu IgM), Clone: LOMK2, Rattus norvegicus Mab antibody-, Biotin
Impad1 antibody, alexa fluor 488 Catalog: bs-6248R-A488 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name IMPAD1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-IMPAD1 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
App ?ctf (human) elisa kit Catalog: KT-1107 | Size: 96 well plate | Price: €949.75 Supplier: Kamiya

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Kamiya <a href="https://clonagen.com/products_by_supplier.php?supplier_name=Kamiya&page=1000&supplier_id=224&search=&filter=" target="_blank" title="https://clonagen.com/products_by_supplier.php?supplier_name=Kamiya&page=1000&supplier_id=224&search=&filter="><i class="fa fa-external-link" aria-hidden="true"></i></a> Alternative name amyloid beta (A4) precursor protein ?CTF (H. sapiens) Enzyme-linked immunosorbent assay reagent Gene target APP ?CTF
Cd41/61 (platelets), clone: capp2a, mouse monoclonal antibody-bovine,goat,sheep Catalog: YV0272-05 | Size: Ask | Price: Ask Supplier: accurate-monoclonals

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Alternative name 1 CD41/61 (platelets), Clone: CAPP2A, Mab anti-Bovine,Goat,Sheep Alternative name 2 CD41/61 (platelets), Clone: CAPP2A, Mab antibody-Bovine,Goat,Sheep Alternative name 3 CD41/61 (platelets), Clone: CAPP2A, Mab antibody-Bovine,Goat,Ovine
Kappa (min x bov,gt,sh,hrs,sw,dog,rab,gp,ch,bab,ms ig's), clone: lo-hk-3, rat mouse monoclonal antibody-human Catalog: YULLOHK3-1 | Size: 1000ul | Price: €814.07 Supplier: accurate-monoclonals

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Alternative name 1 Kappa (min X Bov,Gt,Sh,Hrs,Sw,Dog,Rab,GP,Ch,Bab,Ms Ig's), Clone: LO-HK-3, Rat Mab anti-Human Alternative name 2 Kappa (min X Bov,Gt,Sh,Hrs,Sw,Dog,Rab,GP,Ch,Bab,Ms Ig's), Clone: LO-HK-3, Rat Mab antibody-Human Alternative name 3 Kappa (min X Bov,Gt,Sh,Hrs,Sw,Canine,Rab,GP,Ch,Bab,Ms Ig's), Clone: LO-HK-3, Rattus norvegicus Mab antibody-Homo sapiens
uid :
351

name :
APP

description :
amyloid beta precursor protein

chromosome :
21

geneticsource :
genomic

maplocation :
21q21.3

otheraliases :
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4

otherdesignations :
amyloid-beta A4 protein|alzheimer disease amyloid protein|amyloid beta (A4) precursor protein|amyloid beta A4 protein|amyloid precursor protein|beta-amyloid peptide|beta-amyloid peptide(1-40)|beta-amyloid peptide(1-42)|beta-amyloid precursor protein|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II|testicular tissue protein Li 2

nomenclaturesymbol :
APP

nomenclaturename :
amyloid beta precursor protein

nomenclaturestatus :
Official

geneweight :
308337

chrsort :
21

chrstart :
25880549

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000021.9
chrstart: 26171127
chrstop: 25880549
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000021.9
chrstart: 26171127
chrstop: 25880549
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018932.2
chrstart: 27104968
chrstop: 26813501
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000021.9
chrstart: 26171127
chrstop: 25880549
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018932.2
chrstart: 27104968
chrstop: 26813501
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000021.9
chrstart: 26171127
chrstop: 25880549
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018932.2
chrstart: 27104968
chrstop: 26813501
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000021.8
chrstart: 27543445
chrstop: 27252860
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018932.2
chrstart: 27104968
chrstop: 26813501
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000021.8
chrstart: 27543445
chrstop: 27252860
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018932.1
chrstart: 18087123
chrstop: 17796309
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000021.8
chrstart: 27543445
chrstop: 27252860
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000021.8
chrstart: 27543445
chrstop: 27252860
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000021.8
chrstart: 27543137
chrstop: 27252860
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000064.1
chrstart: 12726566
chrstop: 12436274
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947657
chrstop: 12656349
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000021.8
chrstart: 27543445
chrstop: 27252860
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000064.1
chrstart: 12726874
chrstop: 12436274
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947964
chrstop: 12656349
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000021.7
chrstart: 26465002
chrstop: 26174731
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000064.1
chrstart: 12726560
chrstop: 12436274
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000153.1
chrstart: 12947651
chrstop: 12656349