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AK5: adenylate kinase 5

AK6

Summary

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)

AK5 related publications

Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.

AK5 description

ak5 crispr knockout and activation products (m)

Catalog: sc-432912 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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AK5 CRISPR Knockout and Activation Products (m) AK5 CRISPR Knockout and Activation Products (m) AK5 CRISPR Knockout and Activation Products (m) AK5 CRISPR Knockout and Activation Products (m)

mouse AK5-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

ak5 sirna (h), shrna and lentiviral particle gene silencers

Catalog: sc-72059 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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AK5 siRNA (h), shRNA and Lentiviral Particle Gene Silencers AK5 siRNA (h), shRNA and Lentiviral Particle Gene Silencers AK5 siRNA (h), shRNA and Lentiviral Particle Gene Silencers

human AK5-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

ak5 sirna (m), shrna and lentiviral particle gene silencers

Catalog: sc-72060 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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AK5 siRNA (m), shRNA and Lentiviral Particle Gene Silencers AK5 siRNA (m), shRNA and Lentiviral Particle Gene Silencers AK5 siRNA (m), shRNA and Lentiviral Particle Gene Silencers

mouse AK5-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

ak5 crispr knockout and activation products (h)

Catalog: sc-411909 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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AK5 CRISPR Knockout and Activation Products (h) AK5 CRISPR Knockout and Activation Products (h) AK5 CRISPR Knockout and Activation Products (h) AK5 CRISPR Knockout and Activation Products (h)

human AK5-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

Pak6(ser165) antibody, alexa fluor 350 Catalog: bs-5556R-A350 | Size: 100ul | Price: €420.43 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name PAK6(Ser165) Polyclonal Antibody, ALEXA FLUOR 350 Conjugated Also known as Anti-PAK6 Ser165 PAb ALEXA FLUOR 350 Category Conjugated Primary Antibodies
P21 antibody, alexa fluor 647 Catalog: bs-10129R-A647 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name P21 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-P21 PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Pak6(ser165) antibody Catalog: bs-5556R | Size: 0.1ml | Price: €337.4 Supplier: Bioss Primary Unconjugated Antibodies

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Long name PAK6(Ser165) Primary Polyclonal Antibody Also known as PAK6(Ser165) PAb Category Primary Antibodies
Pak7 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV252104 | Size: 1.0 µg DNA | Price: €387.23 Supplier: ABM lentivectors

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DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
P21 antibody Catalog: GWB-2757FA | Size: 1 x 1 vial | Price: €778.05 Supplier: genways

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Old catalog number 18-272-196222 Storage temperature store cold Expiry date 1 y
Pak5 peptide Catalog: ZP-3075 | Size: 0.05 mg | Price: €244.94 Supplier: Zyagen

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Alternative name PAK5 short protein sequence Gene target PAK5 Peptide Technique peptide
Pak6 peptide Catalog: ZP-3073 | Size: 0.05 mg | Price: €244.94 Supplier: Zyagen

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Alternative name PAK6 short protein sequence Gene target PAK6 Peptide Technique peptide
Human pak5/6 (phospho-ser602/ser560) antibody Catalog: GWB-ASC007 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 50ug:198,100ug:330 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Pak6 rabbit polyclonal antibody Catalog: SIG-3073 | Size: 0.1 mg | Price: €594.35 Supplier: Zyagen

ASK
Alternative name PAK6 production species: rabbit polyclonal (Antibody to) Gene target PAK6 Host Rabbit
Ak5 lentiviral vector (human) (ubc) (plenti-giii-ubc) Catalog: LV072071 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Cleansolutions-co2 Catalog: AK5219-0100 | Size: 100ml | Price: €98.1 Supplier: Akro Albumins and cell culture

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Type of cell culture reagent Cell culture grade Laboratory Clean Solutions Keep at following Temperature 2-8°C for long term storage and shipping at room temperature Literature about cell culture <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860567/" target="_blank" title="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860567/"><i class="fa fa-external-link" aria-hidden="true"></i></a>
P21-activated kinase 7 (pak7) rabbit antibody to or anti-human polyclonal (internal) antibody Catalog: GWB-AFDECB | Size: 1 vial | Price: €722.82 Supplier: genways

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Old catalog number 18-464-436370 Storage temperature store cold Expiry date 1 y
Pak5 rabbit polyclonal antibody Catalog: SIG-3075 | Size: 0.1 mg | Price: €594.35 Supplier: Zyagen

ASK
Alternative name PAK5 production species: rabbit polyclonal (Antibody to) Gene target PAK5 Host Rabbit
Ak5 over-expression lysate reagent Catalog: GWB-354A1B | Size: 1 x 1 vial | Price: €674.79 Supplier: genways

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Old catalog number 36-614-463879 Storage temperature store cold Expiry date 1 y
Pak5 antibody Catalog: bs-0655R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

ASK
Long name PAK5 Primary Polyclonal Antibody Also known as PAK5 PAb Category Primary Antibodies
Human ak5 antibody Catalog: GWB-ASD977 | Size: Ask | Price: Ask Supplier: genways bulk

ASK
Available sizes 50ug:198,100ug:330 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Pak6 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV252098 | Size: 1.0 µg DNA | Price: €387.23 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pak6 antibody, alexa fluor 350 Catalog: bs-4153R-A350 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name PAK6 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated Also known as Anti-PAK6 PAb ALEXA FLUOR 350 Category Conjugated Primary Antibodies
Dna-topoisomerase iiα/β, ~170 & 180kd, clone: ak5, mouse monoclonal antibody-human, mouse, rat, hamster; wb/ip/ihc/facs Catalog: YSGKAMCC215E | Size: 0.1mg | Price: €1552.51 Supplier: accurate-monoclonals

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Alternative name 1 DNA-topoisomerase IIα/β, ~170 & 180kD, Clone: AK5, Mab anti-Human, Mouse, Rat, Hamster; WB/IP/IHC/FACS Alternative name 2 DNA-topoisomerase IIα/β, ~170 & 180kD, Clone: AK5, Mab antibody-Human, Mouse, Rat, Hamster; WB/IP/IHC/FACS Alternative name 3 DNA-topoisomerase IIα/β, ~170 & 180kD, Clone: AK5, Mab antibody-Homo sapiens, Mus musculus, Rattus norvegicus, Hamster; WB/IP/IHC/FACS
Antibody to or anti- p21-activated kinase 6 (pak6) human antibody Catalog: GWB-60FFDA | Size: 1 tube | Price: €1264.34 Supplier: genways

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Old catalog number 18-251-405329 Storage temperature store cold Expiry date 1 y
Pak7 over-expression lysate reagent Catalog: GWB-6235F0 | Size: 1 tube | Price: €1048.21 Supplier: genways

ASK
Old catalog number 36-614-463910 Storage temperature store cold Expiry date 1 y
Pak6 antibody, alexa fluor 647 Catalog: bs-4153R-A647 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name PAK6 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-PAK6 PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Mycosolutions 3 - mycoplasma treatment Catalog: AK5240-0100 | Size: 100ml | Price: €411.84 Supplier: Akro Albumins and cell culture

ASK
Type of cell culture reagent Cell culture grade Mycoplasma Detection/Treatment Keep at following Temperature -20° C/Dry Ice Literature about cell culture <a href="http://clonagen.com/products_by_supplier.php?supplier_name=Akro&page=0&supplier_id=1010&search=&filter=" target="_blank" title="http://clonagen.com/products_by_supplier.php?supplier_name=Akro&page=0&supplier_id=1010&search=&filter="><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pak6 antibody, alexa fluor 555 Catalog: bs-4153R-A555 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name PAK6 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated Also known as Anti-PAK6 PAb ALEXA FLUOR 555 Category Conjugated Primary Antibodies
Ak5 lentiviral vector (human) (cmv) (plenti-giii-cmv-c-term-ha) Catalog: LV072068 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
P21-activated kinase 6 (pak6) rabbit antibody to or anti-human polyclonal antibody Catalog: GWB-6192EC | Size: 1 tube | Price: €722.82 Supplier: genways

ASK
Old catalog number 18-464-435680 Storage temperature store cold Expiry date 1 y
P21 antibody Catalog: bs-10129R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

ASK
Long name P21 Primary Polyclonal Antibody Also known as P21 PAb Category Primary Antibodies
Mycosolutions 3 - mycoplasma treatment Catalog: AK5240-0020 | Size: 20ml | Price: €152.73 Supplier: Akro Albumins and cell culture

ASK
Type of cell culture reagent Cell culture grade Mycoplasma Detection/Treatment Keep at following Temperature -20° C/Dry Ice Literature about cell culture <a href="http://clonagen.com/products_by_supplier.php?supplier_name=Akro&page=0&supplier_id=1010&search=&filter=" target="_blank" title="http://clonagen.com/products_by_supplier.php?supplier_name=Akro&page=0&supplier_id=1010&search=&filter="><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pak6(ser165) antibody, alexa fluor 647 Catalog: bs-5556R-A647 | Size: 100ul | Price: €420.43 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name PAK6(Ser165) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-PAK6 Ser165 PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Anti-pak5/6 (phospho-ser602/ser560) antibody Catalog: A02P0066 | Size: 200ug (50ug, 100ug available) | Price: €558.33 Supplier: Bluegen antibodies

ASK
The antibodie's description anti-EC 2.7.11.1; kinase PAK6; p21-activated kinase 6; PAK 6; PAK-5; PAK-6; PAK5 antibody The antigen used epitope of the human:S602/560, mouse:S602/561 EC 2.7.11.1; kinase PAK6; p21-activated kinase 6; PAK 6; PAK-5; PAK-6; PAK5 antigen Gene name EC 2.7.11.1; kinase PAK6; p21-activated kinase 6; PAK 6; PAK-5; PAK-6; PAK5
P21 antibody, alexa fluor 488 Catalog: bs-10129R-A488 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name P21 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-P21 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
Ak5 lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV072070 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
uid :
26289

name :
AK5

description :
adenylate kinase 5

chromosome :
1

geneticsource :
genomic

maplocation :
1p31.1

otheraliases :
AK6

otherdesignations :
adenylate kinase isoenzyme 5|AK 5|ATP-AMP transphosphorylase 5|adenylate kinase 6

nomenclaturesymbol :
AK5

nomenclaturename :
adenylate kinase 5

nomenclaturestatus :
Official

geneweight :
1060

chrsort :
01

chrstart :
77281907

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000001.11
chrstart: 77281907
chrstop: 77559968
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000001.11
chrstart: 77281907
chrstop: 77559968
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018912.2
chrstart: 77863033
chrstop: 78141540
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000001.11
chrstart: 77281976
chrstop: 77559968
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018912.2
chrstart: 77863033
chrstop: 78141540
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000001.11
chrstart: 77281976
chrstop: 77559968
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878837
chrstop: 76157457
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018912.2
chrstart: 77863033
chrstop: 78141540
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000001.10
chrstart: 77747661
chrstop: 78025653
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878837
chrstop: 76157457
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018912.2
chrstart: 77863033
chrstop: 78141540
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000001.10
chrstart: 77747661
chrstop: 78025653
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878837
chrstop: 76157457
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018912.1
chrstart: 77766148
chrstop: 78044414
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000001.10
chrstart: 77747661
chrstop: 78025653
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878837
chrstop: 76157457
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000001.10
chrstart: 77747661
chrstop: 78025653
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878837
chrstop: 76157457
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000001.10
chrstart: 77747741
chrstop: 78025653
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000044.1
chrstart: 75987127
chrstop: 76265177
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878917
chrstop: 76157457
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000001.10
chrstart: 77747741
chrstop: 78025653
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000044.1
chrstart: 75987127
chrstop: 76265177
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878917
chrstop: 76157457
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000001.9
chrstart: 77520329
chrstop: 77798241
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000044.1
chrstart: 75987127
chrstop: 76265177
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000133.1
chrstart: 75878917
chrstop: 76157457