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AIFM1: apoptosis inducing factor mitochondria associated 1

AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8

Summary

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]

Organism: human (Homo sapiens)

AIFM1 related publications

Molecular characterization of mitochondrial apoptosis-inducing factor.

Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.

AIFM1 description

Aif antibody Catalog: APO-2301 | Size: 0.1 mg | Price: €589.54 Supplier: Zyagen

ASK
Alternative name AIF (Antibody to) Gene target AIF Short name AIF Antibody
Aif antibody Catalog: GWB-3BD8A9 | Size: 1 x 1 vial | Price: €564.33 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Aif antibody Catalog: GWB-B31440 | Size: 1 vial | Price: €438.26 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Aifm1 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV071845 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pdcd8 antibody Catalog: GWB-290A20 | Size: 1 x 1 vial | Price: €583.54 Supplier: genways

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Old catalog number 18-003-44639 Storage temperature store cold Expiry date 1 y
Aif antibody, alexa fluor 647 Catalog: bs-0037R-A647 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name AIF Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-AIF PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Rabbit aif elisa kit Catalog: KT-55516 | Size: 96 well plate | Price: €1309.96 Supplier: Kamiya

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Kamiya <a href="https://clonagen.com/products_by_supplier.php?supplier_name=Kamiya&page=1000&supplier_id=224&search=&filter=" target="_blank" title="https://clonagen.com/products_by_supplier.php?supplier_name=Kamiya&page=1000&supplier_id=224&search=&filter="><i class="fa fa-external-link" aria-hidden="true"></i></a> Alternative name production species: rabbit AIF Enzyme-linked immunosorbent assay reagent Gene target AIF
Anti-aifm1 antibody Catalog: A03A0123 | Size: 200ug (50ug, 100ug available) | Price: €558.33 Supplier: Bluegen antibodies

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The antibodie's description anti-Apoptosis-inducing factor 1, mitochondrial [Precursor], EC 1.-.-.-, Programmed cell death protein 8, AIFM1, AIF, PDCD8 antibody The antigen used epitope of the human, mouse, rat Apoptosis-inducing factor 1, mitochondrial [Precursor], EC 1.-.-.-, Programmed cell death protein 8, AIFM1, AIF, PDCD8 antigen Gene name Apoptosis-inducing factor 1, mitochondrial [Precursor], EC 1.-.-.-, Programmed cell death protein 8, AIFM1, AIF, PDCD8
Aifm1 lentiviral vector (human) (ef1a) (plenti-giii-ef1a) Catalog: LV071850 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aifm1, 98-609aa human, his tag, e.coli Catalog: GWB-ATG0C8 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 100ug:330,500ug:990 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Aif antibody Catalog: GWB-D9978D | Size: 1 vial | Price: €653.18 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Aif peptide Catalog: ZP-2267 | Size: 0.05 mg | Price: €244.94 Supplier: Zyagen

ASK
Alternative name AIF short protein sequence Gene target AIF Peptide Technique peptide
Aif antibody, alexa fluor 594 Catalog: bs-0037R-A594 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name AIF Polyclonal Antibody, ALEXA FLUOR 594 Conjugated Also known as Anti-AIF PAb ALEXA FLUOR 594 Category Conjugated Primary Antibodies
Apoptosis-inducing factor (aifm1 pdcd8) rabbit antibody to or anti-human polyclonal (aa593-606) antibody Catalog: GWB-A99E49 | Size: 1 vial | Price: €722.82 Supplier: genways

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Old catalog number 18-464-436821 Storage temperature store cold Expiry date 1 y
Aif antibody Catalog: APO-2267 | Size: 0.1 mg | Price: €589.54 Supplier: Zyagen

ASK
Alternative name AIF (Antibody to) Gene target AIF Short name AIF Antibody
Aifm1 lentiviral vector (human) (cmv) (plenti-giii-cmv-gfp-2a-puro) Catalog: LV071847 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aif antibody Catalog: bs-0037R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

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Long name AIF Primary Polyclonal Antibody Also known as AIF PAb Category Primary Antibodies
Aifm1 over-expression lysate reagent Catalog: GWB-9259A0 | Size: 1 vial | Price: €1048.21 Supplier: genways

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Old catalog number 36-614-469255 Storage temperature store cold Expiry date 1 y
Aif antibody, alexa fluor 488 Catalog: bs-0037R-A488 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name AIF Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-AIF PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
Apoptosis-inducing factor (aifm1 pdcd8) rabbit antibody to or anti-human polyclonal (aa517-531) antibody Catalog: GWB-5FF138 | Size: 1 tube | Price: €778.05 Supplier: genways

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Old catalog number 18-464-435091 Storage temperature store cold Expiry date 1 y
Aifm1 lentiviral vector (human) (cmv) (plenti-giii-cmv-c-term-ha) Catalog: LV071846 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aif antibody Catalog: APO-2239 | Size: 0.1 mg | Price: €589.54 Supplier: Zyagen

ASK
Alternative name AIF (Antibody to) Gene target AIF Short name AIF Antibody
Antibody to or anti-apoptosis inducing factor (aif) antibody Catalog: GWB-88504E | Size: 1 vial | Price: €688 Supplier: genways

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Old catalog number 18-732-292243 Storage temperature store cold Expiry date 1 y
Aif antibody Catalog: GWB-866615 | Size: 1 vial | Price: €564.33 Supplier: genways

ASK
Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Aifm1 lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV071848 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aif peptide Catalog: ZP-2301 | Size: 0.05 mg | Price: €244.94 Supplier: Zyagen

ASK
Alternative name AIF short protein sequence Gene target AIF Peptide Technique peptide
Aif peptide Catalog: ZP-2239 | Size: 0.05 mg | Price: €244.94 Supplier: Zyagen

ASK
Alternative name AIF short protein sequence Gene target AIF Peptide Technique peptide
Aif antibody, alexa fluor 350 Catalog: bs-0037R-A350 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name AIF Polyclonal Antibody, ALEXA FLUOR 350 Conjugated Also known as Anti-AIF PAb ALEXA FLUOR 350 Category Conjugated Primary Antibodies
Aif antibody, alexa fluor 555 Catalog: bs-0037R-A555 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name AIF Polyclonal Antibody, ALEXA FLUOR 555 Conjugated Also known as Anti-AIF PAb ALEXA FLUOR 555 Category Conjugated Primary Antibodies
Aifm1 antibody Catalog: GWB-MX363C | Size: 1 vial | Price: €625.56 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Aifm1 lentiviral vector (human) (ubc) (plenti-giii-ubc) Catalog: LV071849 | Size: 1.0 µg DNA | Price: €621.36 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pdcd8 antibody Catalog: GWB-F87A32 | Size: 1 vial | Price: €583.54 Supplier: genways

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Old catalog number 18-003-44154 Storage temperature store cold Expiry date 1 y
Aifm1 antibody Catalog: R31851 | Size: 0.1mg | Price: €487.48 Supplier: NJS poly

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Category Antibody Concentration 0.5mg/ml if reconstituted with 0.2ml sterile DI water Form Antigen affinity purified
Aifm1 antibody Catalog: R33400-100UG | Size: 0.1mg | Price: €487.48 Supplier: NJS poly

ASK
Category Antibody Concentration 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide Form Antigen affinity purified
uid :
9131

name :
AIFM1

description :
apoptosis inducing factor mitochondria associated 1

chromosome :
X

geneticsource :
genomic

maplocation :
Xq26.1

otheraliases :
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8

otherdesignations :
apoptosis-inducing factor 1, mitochondrial|apoptosis-inducing factor, mitochondrion-associated, 1|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor|testicular secretory protein Li 4

nomenclaturesymbol :
AIFM1

nomenclaturename :
apoptosis inducing factor mitochondria associated 1

nomenclaturestatus :
Official

geneweight :
25099

chrsort :
X

chrstart :
130129361

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000023.11
chrstart: 130165886
chrstop: 130129361
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000023.11
chrstart: 130165886
chrstop: 130129361
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018934.2
chrstart: 129211490
chrstop: 129174948
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000023.11
chrstart: 130165886
chrstop: 130129361
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018934.2
chrstart: 129211490
chrstop: 129174948
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000023.11
chrstart: 130165886
chrstop: 130129361
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018934.2
chrstart: 129211490
chrstop: 129174948
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000023.10
chrstart: 129299860
chrstop: 129263336
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018934.2
chrstart: 129211490
chrstop: 129174948
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000023.10
chrstart: 129299860
chrstop: 129263336
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018934.1
chrstart: 129255682
chrstop: 129219081
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000023.10
chrstart: 129299860
chrstop: 129263336
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000023.10
chrstart: 129299860
chrstop: 129263336
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000023.10
chrstart: 129299860
chrstop: 129263336
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000066.1
chrstart: 129686422
chrstop: 129649900
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695646
chrstop: 118659693
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000023.10
chrstart: 129299807
chrstop: 129263336
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000066.1
chrstart: 129686369
chrstop: 129649900
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695593
chrstop: 118659693
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000023.9
chrstart: 129127488
chrstop: 129091017
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000066.1
chrstart: 129686369
chrstop: 129649900
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000155.1
chrstart: 118695593
chrstop: 118659693