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AFF3: AF4/FMR2 family member 3

LAF4, MLLT2-like

Summary

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)

AFF3 related publications

LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12.

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.

AFF3 description

laf4 crispr knockout and activation products (m)

Catalog: sc-421369 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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LAF4 CRISPR Knockout and Activation Products (m) LAF4 CRISPR Knockout and Activation Products (m) LAF4 CRISPR Knockout and Activation Products (m) LAF4 CRISPR Knockout and Activation Products (m)

mouse LAF4-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

laf4 sirna (h), shrna and lentiviral particle gene silencers

Catalog: sc-94401 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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LAF4 siRNA (h), shRNA and Lentiviral Particle Gene Silencers LAF4 siRNA (h), shRNA and Lentiviral Particle Gene Silencers LAF4 siRNA (h), shRNA and Lentiviral Particle Gene Silencers

human LAF4-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

laf4 sirna (m), shrna and lentiviral particle gene silencers

Catalog: sc-146636 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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LAF4 siRNA (m), shRNA and Lentiviral Particle Gene Silencers LAF4 siRNA (m), shRNA and Lentiviral Particle Gene Silencers LAF4 siRNA (m), shRNA and Lentiviral Particle Gene Silencers

mouse LAF4-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to 2 (mllt2) (aff1) rabbit antibody to or anti-human polyclonal ( Catalog: GWB-EF7623 | Size: 1 vial | Price: €722.82 Supplier: genways

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Old catalog number 18-464-435583 Storage temperature store cold Expiry date 1 y
Rat antibody to or anti-mouse cd45 (lca), antibody Catalog: GWB-AFF308 | Size: 1 vial | Price: €695.21 Supplier: genways

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Old catalog number 20-787-275430 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-F00EA0 | Size: 1 vial | Price: €805.67 Supplier: genways

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Old catalog number 20-321-175062 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-F6CB19 | Size: 1 vial | Price: €682 Supplier: genways

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Old catalog number 20-321-175056 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-75AA46 | Size: 1 tube | Price: €682 Supplier: genways

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Old catalog number 20-321-175050 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-89E3B7 | Size: 1 vial | Price: €682 Supplier: genways

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Old catalog number 20-321-175146 Storage temperature store cold Expiry date 1 y
Synthetic human glucagon-like peptide sequence 2 protein Catalog: GWB-Q00425 | Size: 1 vial | Price: €459.87 Supplier: genways

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Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Recombinant human insulin-like growth factor i Catalog: GWB-BA0D90 | Size: 1 vial | Price: €737.23 Supplier: genways

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Old catalog number 10-783-313252 Storage temperature store cold Expiry date 1 y
Aff3 lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV070666 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-F92B96 | Size: 1 vial | Price: €542.72 Supplier: genways

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Old catalog number 20-321-175079 Storage temperature store cold Expiry date 1 y
Toll-like receptor 9 (tlr9. cd289), antibody Catalog: GWB-CF8A75 | Size: 1 vial | Price: €682 Supplier: genways

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Old catalog number 20-321-175166 Storage temperature store cold Expiry date 1 y
Toll-like receptor 4 (tlr4. cd284), antibody Catalog: GWB-C5148D | Size: 1 vial | Price: €682 Supplier: genways

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Old catalog number 20-321-175149 Storage temperature store cold Expiry date 1 y
Toll-like receptor 4 (tlr4. cd284), antibody Catalog: GWB-F7C465 | Size: 1 vial | Price: €542.72 Supplier: genways

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Old catalog number 20-321-175151 Storage temperature store cold Expiry date 1 y
Toll-like receptor 9 (tlr9. cd289), antibody Catalog: GWB-86AFF8 | Size: 1 vial | Price: €542.72 Supplier: genways

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Old catalog number 20-321-175046 Storage temperature store cold Expiry date 1 y
Aff3 lentiviral vector (human) (cmv) (plenti-giii-cmv-gfp-2a-puro) Catalog: LV070665 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-1BDE13 | Size: 1 x 1 vial | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175147 Storage temperature store cold Expiry date 1 y
Toll-like receptor 1 (tlr1. cd281), antibody Catalog: GWB-EA7878 | Size: 1 vial | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175164 Storage temperature store cold Expiry date 1 y
Setd8 over-expression lysate reagent Catalog: GWB-4BAFF3 | Size: 1 x 1 vial | Price: €555.92 Supplier: genways

ASK
Old catalog number 36-614-463213 Storage temperature store cold Expiry date 1 y
Toll-like receptor 4 (tlr4. cd284) /md-2, antibody Catalog: GWB-175B53 | Size: 1 x 1 vial | Price: €682 Supplier: genways

ASK
Old catalog number 20-321-175035 Storage temperature store cold Expiry date 1 y
Toll-like receptor 3 (tlr3. cd283), antibody Catalog: GWB-7E13B4 | Size: 1 tube | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175172 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-3AFFAA | Size: 1 x 1 vial | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175063 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-D1B2C9 | Size: 1 vial | Price: €682 Supplier: genways

ASK
Old catalog number 20-321-175061 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-361BB6 | Size: 1 x 1 vial | Price: €682 Supplier: genways

ASK
Old catalog number 20-321-175143 Storage temperature store cold Expiry date 1 y
Toll-like receptor 4 (tlr4. cd284), antibody Catalog: GWB-63F59B | Size: 1 tube | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175150 Storage temperature store cold Expiry date 1 y
Toll-like receptor 3 (tlr3. cd283), antibody Catalog: GWB-2F1A3D | Size: 1 x 1 vial | Price: €682 Supplier: genways

ASK
Old catalog number 20-321-175170 Storage temperature store cold Expiry date 1 y
Aff3 lentiviral vector (human) (cmv) (plenti-giii-cmv-c-term-ha) Catalog: LV070664 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Pnrc2 over-expression lysate reagent Catalog: GWB-BCAFF3 | Size: 1 vial | Price: €555.92 Supplier: genways

ASK
Old catalog number 36-614-467345 Storage temperature store cold Expiry date 1 y
Antibody to or anti- b galactosidase antibody Catalog: GWB-AFF361 | Size: 1 vial | Price: €695.21 Supplier: genways

ASK
Old catalog number 18-251-405053 Storage temperature store cold Expiry date 1 y
Fitc conjugated labelled toll-like receptor 3 (tlr3. cd283), antibody Catalog: GWB-5D0F40 | Size: 1 tube | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175171 Storage temperature store cold Expiry date 1 y
Aff3 lentiviral vector (human) (ubc) (plenti-giii-ubc) Catalog: LV070667 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aff3 antibody Catalog: GWB-ML800H | Size: 1 vial | Price: €625.56 Supplier: genways

ASK
Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-8796A3 | Size: 1 vial | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175058 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-756CDD | Size: 1 tube | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175148 Storage temperature store cold Expiry date 1 y
Toll-like receptor 1 (tlr1. cd281), antibody Catalog: GWB-CCB3EA | Size: 1 vial | Price: €660.39 Supplier: genways

ASK
Old catalog number 20-321-175165 Storage temperature store cold Expiry date 1 y
Toll-like receptor 1 (tlr1. cd281), antibody Catalog: GWB-BDA142 | Size: 1 vial | Price: €682 Supplier: genways

ASK
Old catalog number 20-321-175163 Storage temperature store cold Expiry date 1 y
Monoclonal antibody tomouse toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-E63E64 | Size: 1 vial | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175051 Storage temperature store cold Expiry date 1 y
Toll-like receptor 4 (tlr4. cd284) /md-2, antibody Catalog: GWB-708F12 | Size: 1 tube | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175036 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-61E201 | Size: 1 tube | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175144 Storage temperature store cold Expiry date 1 y
Peroxisome proliferator-activated receptor gamma (pparg) rabbit antibody to or anti-human polyclonal (internal) antibody Catalog: GWB-DBAFF3 | Size: 1 vial | Price: €722.82 Supplier: genways

ASK
Old catalog number 18-464-436589 Storage temperature store cold Expiry date 1 y
Toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-3F3537 | Size: 1 x 1 vial | Price: €542.72 Supplier: genways

ASK
Old catalog number 20-321-175145 Storage temperature store cold Expiry date 1 y
Aff3 antibody Catalog: GWB-MM681F | Size: 1 vial | Price: €625.56 Supplier: genways

ASK
Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Cd146 human -biotin conjugated, antibody Catalog: GWB-C3AFF3 | Size: 1 vial | Price: €1527.29 Supplier: genways

ASK
Old catalog number 20-251-401596 Storage temperature store cold Expiry date 1 y
Fitc conjugated labelled toll-like receptor 2 (tlr2. cd282), antibody Catalog: GWB-CAD3AE | Size: 1 vial | Price: €805.67 Supplier: genways

ASK
Old catalog number 20-321-175057 Storage temperature store cold Expiry date 1 y
Aff3 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV070663 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
uid :
3899

name :
AFF3

description :
AF4/FMR2 family member 3

chromosome :
2

geneticsource :
genomic

maplocation :
2q11.2

otheraliases :
LAF4, MLLT2-like

otherdesignations :
AF4/FMR2 family member 3|MLLT2-related protein|lymphoid nuclear protein 4|lymphoid nuclear protein related to AF4|protein LAF-4

nomenclaturesymbol :
AFF3

nomenclaturename :
AF4/FMR2 family member 3

nomenclaturestatus :
Official

geneweight :
2675

chrsort :
02

chrstart :
99545860

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000002.12
chrstart: 100142582
chrstop: 99545860
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000002.12
chrstart: 100142582
chrstop: 99545860
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018913.2
chrstart: 100763378
chrstop: 100168033
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000002.12
chrstart: 100142582
chrstop: 99545863
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018913.2
chrstart: 100763378
chrstop: 100168033
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000002.12
chrstart: 100142574
chrstop: 99545863
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018913.2
chrstart: 100763378
chrstop: 100168033
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100162325
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018913.2
chrstart: 100763378
chrstop: 100168033
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100163714
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018913.1
chrstart: 100414924
chrstop: 99819816
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100163714
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100163714
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100163714
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000045.1
chrstart: 94963583
chrstop: 94368401
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000002.11
chrstart: 100759036
chrstop: 100163714
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000045.1
chrstart: 94963583
chrstop: 94368401
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928917
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000002.10
chrstart: 100125468
chrstop: 99530146
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000045.1
chrstart: 94963583
chrstop: 94368401
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000134.1
chrstart: 94523830
chrstop: 93928915