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All about genes

AF4 antibody

Af4 antibody Catalog: 70R-51589 | Size: 100 µl | Price: €644.78 Supplier: fitzgerald ASK
Category: Primary Antibody Antibody Subtype: Polyclonal Antibodies, Purified Area of research: DNA & RNA

AFF1 gene: AF4/FMR2 family member 1

AF4, MLLT2, PBM1

Summary

This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Organism: human (Homo sapiens)