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AF-4 CRISPR Knockout and Activation Products (m)

af-4 crispr knockout and activation products (m) Catalog: sc-421662 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology ASK
 AF-4 CRISPR Knockout and Activation Products (m)  AF-4 CRISPR Knockout and Activation Products (m)  AF-4 CRISPR Knockout and Activation Products (m)  AF-4 CRISPR Knockout and Activation Products (m)

mouse AF-4-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

AFF1 gene: AF4/FMR2 family member 1

AF4, MLLT2, PBM1

Summary

This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Organism: human (Homo sapiens)