Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Available sizes 50ug:198,100ug:330Store store in freezer for long therm or fridge for short time storageCategory research antibodies, ELISAs, e. Coli rec. human proteins
Alternative name 1 BAI1-Associated Protein 2-Like 1, Mab anti-; Clone: 2A4Alternative name 2 BAI1-Associated Protein 2-Like 1, Mab antibody-; Clone: 2A4Alternative name 3 BAI1-Associated Protein 2-Like 1, Mab antibody-; Clone: 2A4
The antibodie's description anti-Brain-specific angiogenesis inhibitor 1 antibodyThe antigen used epitope of the human, mouse Brain-specific angiogenesis inhibitor 1 antigenGene name Brain-specific angiogenesis inhibitor 1
Gene info BAI1 is an Orphan-B GPCR with an unknown ligand. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis, and a growth suppressor of glioblastoma. Along with BAI1, there are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3, which have similar tissue specificities and structures. However, only BAI1 is transcriptionally regulated by p53. Loss of BAI1 expression has been implicated in glioblastoma.Gene names BAI1, GDAIFAntibodie's label unlabelled serum
Category Primary AntibodiesLong description BAI1 is an Orphan-B GPCR with an unknown ligand. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis, and a growth suppressor of glioblastoma. Along with BAI1, there are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3, which have similar tissue specificities and structures. However, only BAI1 is transcriptionally regulated by p53. Loss of BAI1 expression has been implicated in glioblastoma.Antibody come from Synthetic peptide derived from the N-terminal extracellular domain of human CERK