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anti-Alpha-actinin-2 / ACTN2 (C-term) Antibody

Anti-alpha-actinin-2 / actn2 (c-term) antibody Catalog: AP50071PU-N | Size: 0,4 ml | Price: €704.81 Supplier: acr ASK
Vial description: Alpha actinin skeletal muscle isoform 2 Category: primary antibody Raised in: Rabbit

ACTN2 gene: actinin alpha 2



Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Organism: human (Homo sapiens)