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ACO1: aconitase 1

ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1

Summary

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Organism: human (Homo sapiens)

ACO1 related publications

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.

ACO1 description

irp-1 antibody (e-12)

Catalog: sc-166022 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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IRP-1 Antibody (E-12) IRP-1 Antibody (E-12)

recommended for detection of IRP-1 of mouse, rat and human origin by WB, IP, IF and ELISA

irp-1 antibody (n-17)

Catalog: sc-14216 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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IRP-1 Antibody (N-17) IRP-1 Antibody (N-17) IRP-1 Antibody (N-17) IRP-1 Antibody (N-17)

DISCONTINUED: recommended for detection of IRP-1 of mouse, rat and human origin by WB, IP, IF and ELISA

irp-1 crispr knockout and activation products (m)

Catalog: sc-418946 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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IRP-1 CRISPR Knockout and Activation Products (m) IRP-1 CRISPR Knockout and Activation Products (m) IRP-1 CRISPR Knockout and Activation Products (m) IRP-1 CRISPR Knockout and Activation Products (m)

mouse IRP-1-specific CRISPR/Cas9 KO Plasmid, HDR Plasmid, Double Nickase Plasmids, CRISPR Activation Plasmids and Lentiviral Activation Particles

irp-1 sirna (h), shrna and lentiviral particle gene silencers

Catalog: sc-40713 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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IRP-1 siRNA (h), shRNA and Lentiviral Particle Gene Silencers IRP-1 siRNA (h), shRNA and Lentiviral Particle Gene Silencers IRP-1 siRNA (h), shRNA and Lentiviral Particle Gene Silencers

human IRP-1-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

irp-1 sirna (m), shrna and lentiviral particle gene silencers

Catalog: sc-40714 | Size: Ask | Price: Ask Supplier: Santa Cruz Biotechnology

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IRP-1 siRNA (m), shRNA and Lentiviral Particle Gene Silencers IRP-1 siRNA (m), shRNA and Lentiviral Particle Gene Silencers IRP-1 siRNA (m), shRNA and Lentiviral Particle Gene Silencers

mouse IRP-1-specific siRNA, shRNA Plasmid and Lentiviral Particle gene silencers

Taco1 antibody, alexa fluor 594 Catalog: bs-16128R-A594 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name TACO1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated Also known as Anti-TACO1 PAb ALEXA FLUOR 594 Category Conjugated Primary Antibodies
Aco1 antibody Catalog: GWB-8E729D | Size: 1 vial | Price: €583.54 Supplier: genways

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Old catalog number 18-003-43581 Storage temperature store cold Expiry date 1 y
Aconitase 1 antibody, alexa fluor 350 Catalog: bs-9848R-A350 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name Aconitase 1 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated Also known as Anti-Aconitase 1 PAb ALEXA FLUOR 350 Category Conjugated Primary Antibodies
Human ireb1 (ab-138) antibody Catalog: GWB-ASC529 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 50ug:198,100ug:330 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Rnf187 antibody, alexa fluor 555 Catalog: bs-9283R-A555 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name RNF187 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated Also known as Anti-RNF187 PAb ALEXA FLUOR 555 Category Conjugated Primary Antibodies
Rnf187 antibody, alexa fluor 647 Catalog: bs-9283R-A647 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name RNF187 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-RNF187 PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Aco1, 1-889aa, recombinant protein Catalog: GWB-P1167J | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 10ug:330,50ug:990 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Tmem57 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV337014 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

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DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aconitase 1 antibody, alexa fluor 647 Catalog: bs-9848R-A647 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name Aconitase 1 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated Also known as Anti-Aconitase 1 PAb ALEXA FLUOR 647 Category Conjugated Primary Antibodies
Aconitase 1 antibody, alexa fluor 555 Catalog: bs-9848R-A555 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name Aconitase 1 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated Also known as Anti-Aconitase 1 PAb ALEXA FLUOR 555 Category Conjugated Primary Antibodies
Rnf187 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV289959 | Size: 1.0 µg DNA | Price: €720.42 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Taco1 over-expression lysate reagent Catalog: GWB-E7D9BD | Size: 1 vial | Price: €555.92 Supplier: genways

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Old catalog number 36-614-463024 Storage temperature store cold Expiry date 1 y
Aco1 over-expression lysate reagent Catalog: GWB-D78818 | Size: 1 vial | Price: €674.79 Supplier: genways

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Old catalog number 36-614-461562 Storage temperature store cold Expiry date 1 y
Rnf187 antibody, alexa fluor 488 Catalog: bs-9283R-A488 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

ASK
Long name RNF187 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-RNF187 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
Aconitase 1 antibody, alexa fluor 488 Catalog: bs-9848R-A488 | Size: 100ul | Price: €399.53 Supplier: Bioss Primary Conjugated Antibodies. ALEXA FLUOR

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Long name Aconitase 1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated Also known as Anti-Aconitase 1 PAb ALEXA FLUOR 488 Category Conjugated Primary Antibodies
Monkey macoilin (tmem57) elisa kit Catalog: AE59590MK | Size: 96 wells plate | Price: €972.57 Supplier: ab-elisa elisas

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Also known as Macoilin (TMEM57) ELISA kit Species reactivity Monkey Recognised antigen Macoilin
Human ireb1 (phospho-ser711) antibody Catalog: GWB-ASB505 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 50ug:198,100ug:330 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Tmem57 over-expression lysate reagent Catalog: GWB-5B61D2 | Size: 1 x 1 vial | Price: €555.92 Supplier: genways

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Old catalog number 36-614-467209 Storage temperature store cold Expiry date 1 y
Aco1 human protein Catalog: GWB-BSP118 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 1ug:83,5ug:182,50ug:1579 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Human ireb1 (phospho-ser138) antibody Catalog: GWB-ASB506 | Size: Ask | Price: Ask Supplier: genways bulk

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Available sizes 50ug:198,100ug:330 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Rnf187 antibody Catalog: bs-9283R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

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Long name RNF187 Primary Polyclonal Antibody Also known as RNF187 PAb Category Primary Antibodies
Taco1 antibody Catalog: bs-16128R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

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Long name TACO1 Primary Polyclonal Antibody Also known as TACO1 PAb Category Primary Antibodies
Aco1 lentiviral vector (human) (ubc) (plenti-giii-ubc) Catalog: LV067186 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aconitase 1 antibody Catalog: bs-9848R | Size: 0.1ml | Price: €315.78 Supplier: Bioss Primary Unconjugated Antibodies

ASK
Long name Aconitase 1 Primary Polyclonal Antibody Also known as Aconitase 1 PAb Category Primary Antibodies
Aco1 lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV067182 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="http://xelonet.com/abm/" target="_blank" title="http://xelonet.com/abm/"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aco1 lentiviral vector (human) (ef1a) (plenti-giii-ef1a) Catalog: LV067187 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
Aco1 lentiviral vector (human) (cmv) (plenti-giii-cmv-c-term-ha) Catalog: LV067183 | Size: 1.0 µg DNA | Price: €1350.79 Supplier: ABM lentivectors

ASK
DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files <a href="https://www.abmgood.com/UbC-Lentivirus-System.html" target="_blank" title="https://www.abmgood.com/UbC-Lentivirus-System.html"><i class="fa fa-external-link" aria-hidden="true"></i></a> Lentivirus references <a href="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf" target="_blank" title="http://compbio.dfci.harvard.edu/compbio/research/labprotocols/contentBlocks/0/contentBlock_files/file15/Lentivirus_Production_and_Transfection_Protocol.pdf"><i class="fa fa-external-link" aria-hidden="true"></i></a>
uid :
48

name :
ACO1

description :
aconitase 1

chromosome :
9

geneticsource :
genomic

maplocation :
9p21.1

otheraliases :
ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1

otherdesignations :
cytoplasmic aconitate hydratase|aconitase 1, soluble|aconitate hydratase, cytoplasmic|citrate hydro-lyase|cytoplasmic aconitase|cytosplasmic aconitase|epididymis luminal protein 60|ferritin repressor protein|iron regulatory protein 1|iron-responsive element-binding protein 1|soluble aconitase

nomenclaturesymbol :
ACO1

nomenclaturename :
aconitase 1

nomenclaturestatus :
Official

geneweight :
7971

chrsort :
09

chrstart :
32384602

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000009.12
chrstart: 32384602
chrstop: 32450835
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000009.12
chrstart: 32384602
chrstop: 32450835
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018920.2
chrstart: 32384454
chrstop: 32450691
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000009.12
chrstart: 32384602
chrstop: 32450835
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018920.2
chrstart: 32384454
chrstop: 32450691
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000009.12
chrstart: 32384602
chrstop: 32450835
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018920.2
chrstart: 32384454
chrstop: 32450691
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018920.2
chrstart: 32384454
chrstop: 32450691
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018920.1
chrstart: 32354930
chrstop: 32421172
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000052.1
chrstart: 32314540
chrstop: 32380795
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000009.11
chrstart: 32384600
chrstop: 32450833
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000052.1
chrstart: 32314540
chrstop: 32380795
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340336
chrstop: 32406623
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000009.10
chrstart: 32374649
chrstop: 32440829
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000052.1
chrstart: 32314589
chrstop: 32380791
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000141.1
chrstart: 32340385
chrstop: 32406619