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anti-ABCC5 / MRP5 Antibody

Anti-abcc5 / mrp5 antibody Catalog: AM32044SU-N | Size: 1 ml | Price: €791.26 Supplier: acr ASK
Vial description: Multidrug resistance-associated protein 5ABC11, SMRP, MOAT-C Category: primary antibody Clonality: monoclonal

ABCC5 gene: ATP binding cassette subfamily C member 5

ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Organism: human (Homo sapiens)