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Human Abcc2 CRISPR Knock Out A549 Cell Line

Human abcc2 crispr knock out a549 cell line Catalog: K0019153 | Size: 1x10^6 cells/1.0ml | Price: €6989.27 Supplier: ABM CrispR ASK
Cell line type: A549 NCBI number: NM_000392 Availability: Please contact us every day to check the availability and/or to request a quote. For larger or bulk quantities a discount may apply.

ABCC2 gene: ATP binding cassette subfamily C member 2

ABC30, CMOAT, DJS, MRP2, cMRP

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)