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ATP Binding Cassette Transporter C2 (ABCC2) Polyclonal Antibody

Atp binding cassette transporter c2 (abcc2) polyclonal antibody Catalog: CAU23226 | Size: 10 μg | Price: €205.32 Supplier: bioma ASK
Other name: CMOAT1; ABC30; CMOAT; DJS; MRP2; cMRP; Canalicular Multispecific Organic Anion transporter 1; Canalicular multidrμg resistance protein; Multidrμg resistance-associated 2 Immunogen: ABCC2 (Ile1300~Glu1534) Verified reactivity: Homo sapiens (Human)

ABCC2 gene: ATP binding cassette subfamily C member 2

ABC30, CMOAT, DJS, MRP2, cMRP

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Organism: human (Homo sapiens)