Gen-script
All about genes

CD91, Clone: A2Mr alpha-2, Mouse Monoclonal antibody-; RPE

Cd91, clone: a2mr alpha-2, mouse monoclonal antibody-; rpe Catalog: YM4074R | Size: 100 tests | Price: €1600.53 Supplier: accurate-monoclonals

Alternative name 1: CD91, Clone: A2Mr alpha-2, Mab anti-; RPE Alternative name 2: CD91, Clone: A2Mr alpha-2, Mab antibody-; RPE Alternative name 3: CD91, Clone: A2Mr alpha-2, Mab antibody-; RPE

A2M gene: alpha-2-macroglobulin

A2MD, CPAMD5, FWP007, S863-7

Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Organism: human (Homo sapiens)