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All about genes

A2M: alpha-2-macroglobulin

A2MD, CPAMD5, FWP007, S863-7

Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Organism: human (Homo sapiens)

A2M description

Anti-human macroglobulin alpha 2 Catalog: 101-M560 | Size: 100ug | Price: €403.44 Supplier: Reliatech antibodies

Gene Name Macroglobulin alpha 2 Species Reactivity Human (Homo sapiens) Synonyms A2M; A2MD; CPAMD5; FWP007; S863-7
Cd91 antibody (biotin conjugated) Catalog: GWB-E4973A | Size: 1 vial | Price: €882.51 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Alpha 2 macroglobulin Catalog: GWB-1A733A | Size: 1 x 1 vial | Price: €638.77 Supplier: genways

Old catalog number 11-783-79585 Storage temperature store cold Expiry date 1 y
A2m lentiviral vector (human) (cmv) (plenti-giii-cmv-gfp-2a-puro) Catalog: LV063938 | Size: 1.0 µg DNA | Price: €3187.86 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
Lrp/ a2mr (85kd) human, antibody Catalog: GWB-71EF7E | Size: 1 tube | Price: €1014.59 Supplier: genways

Old catalog number 20-251-400969 Storage temperature store cold Expiry date 1 y
Multi-drug resistance related protein (mdr), p-glycoprotein p170, 170-180kd, clone: jsb-1, mouse monoclonal antibody-hu, cytospin/frozen/paraffin Catalog: YM9011-5 | Size: 5 ml | Price: €4766.78 Supplier: accurate-monoclonals

Alternative name 1 Multi-Drug Resistance Related Protein (MDR), P-Glycoprotein P170, 170-180kD, Clone: JSB-1, Mab anti-Hu, cytospin/frozen/paraffin Alternative name 2 Multi-Drug Resistance Related Protein (MDR), P-Glycoprotein P170, 170-180kD, Clone: JSB-1, Mab antibody-Hu, cytospin/frozen/paraffin Alternative name 3 Multi-Drug Resistance Related Protein (MDR), P-Glycoprotein P170, 170-180kD, Clone: JSB-1, Mab antibody-Hu, cytospin/frozen/paraffin
Lrp1 antibody Catalog: GWB-MV306I | Size: 1 vial | Price: €625.56 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Receptor-associated protein (rap) (recombinant) rat Catalog: GWB-204370 | Size: 1 x 1 vial | Price: €2401.4 Supplier: genways

Old catalog number 10-251-407402 Storage temperature store cold Expiry date 1 y
Cd91, alpha-2-macroglobulin receptor, clone: alpha 2mr alpha-2, mouse monoclonal antibody-human; frozen, ih/flow/elisa/ip/wb Catalog: OBT4467 | Size: Ask | Price: Ask Supplier: accurate-monoclonals

Alternative name 1 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab anti-Human; frozen, IH/flow/ELISA/IP/WB Alternative name 2 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Human; frozen, IH/flow/ELISA/IP/WB Alternative name 3 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Homo sapiens; frozen, IH/flow/ELISA/IP/WB
Cd91 antibody Catalog: GWB-48DFC9 | Size: 1 x 1 vial | Price: €555.92 Supplier: genways

Old catalog number 20-272-193831 Storage temperature store cold Expiry date 1 y
Lrpap1 over-expression lysate reagent Catalog: GWB-F3433C | Size: 1 vial | Price: €555.92 Supplier: genways

Old catalog number 36-614-469883 Storage temperature store cold Expiry date 1 y
Alpha-2-macroglobulin (a2m) goat antibody to or anti-human polyclonal antibody Catalog: GWB-879638 | Size: 1 vial | Price: €722.82 Supplier: genways

Old catalog number 18-464-436908 Storage temperature store cold Expiry date 1 y
Lrpap1, 35-357aa, recombinant protein Catalog: GWB-P0654D | Size: Ask | Price: Ask Supplier: genways bulk

Available sizes 100ug:330,500ug:990 Store store in freezer for long therm or fridge for short time storage Category research antibodies, ELISAs, e. Coli rec. human proteins
Human alpha 2-macroglobulin (a2m) 96 well plate elisa assay Catalog: GWB-DM3742 | Size: 1 vial | Price: €578.74 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
A2m antibody Catalog: GWB-MV529G | Size: 1 vial | Price: €625.56 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Cd91 antibody (preservativefree) Catalog: GWB-FB878D | Size: 1 vial | Price: €1970.35 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Cd91, alpha-2-macroglobulin receptor, clone: alpha 2mr alpha-2, mouse monoclonal antibody-human Catalog: YSRTMCA1965GA | Size: 0.1 mg | Price: €279.76 Supplier: accurate-monoclonals

Alternative name 1 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab anti-Human Alternative name 2 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Human Alternative name 3 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Homo sapiens
Cd91, alpha-2-macroglobulin receptor, clone: alpha 2mr alpha-2, mouse monoclonal antibody-human, azide-free Catalog: YSRTMCA1965XZ | Size: 1 mg | Price: €1236.72 Supplier: accurate-monoclonals

Alternative name 1 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab anti-Human, azide-free Alternative name 2 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Human, azide-free Alternative name 3 CD91, Alpha-2-Macroglobulin Receptor, Clone: Alpha 2MR alpha-2, Mab antibody-Homo sapiens, azide-free
Alpha 2 macroglobulin antibody (hrp) Catalog: GWB-5566FB | Size: 1 x 1 vial | Price: €682 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Lrpap1 antibody Catalog: GWB-51B3DA | Size: 1 x 1 vial | Price: €493.49 Supplier: genways

Old catalog number 18-003-44552 Storage temperature store cold Expiry date 1 y
A2m lentiviral vector (human) (cmv) (plenti-giii-cmv-rfp-2a-puro) Catalog: LV063939 | Size: 1.0 µg DNA | Price: €3187.86 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
A2m lentiviral vector (human) (ef1a) (plenti-giii-ef1a) Catalog: LV063941 | Size: 1.0 µg DNA | Price: €3187.86 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
A2m lentiviral vector (human) (cmv) (plenti-giii-cmv) Catalog: LV063936 | Size: 1.0 µg DNA | Price: €3187.86 Supplier: ABM lentivectors

DNA lentivector for transduction information Lentiveral packaging plasmid DNA for non-viral plasmid transfection and direct use in plasmid expression. This DNA can alos be used for packaging into Lentiviral particles for high efficiency transduction and stably integrated expressions. GENTAUR suggests to use our ABM packaging mix LV003 of second generation virusses or the LV053, our 3rd Generation Packaging mixture. pLenti lentiviral plasmids DNAs are stored in 10milliMolar Tris/HCI with 1mM EDTA at a pH of 8 at -25 C. Vectors with selection markers like kanamycin, puromycin or cumate are available. Lentiviral technical files Lentivirus references
Cd91, clone: a2mr alpha-2, mouse monoclonal antibody-; rpe Catalog: YM4074R | Size: 100 tests | Price: €1600.53 Supplier: accurate-monoclonals

Alternative name 1 CD91, Clone: A2Mr alpha-2, Mab anti-; RPE Alternative name 2 CD91, Clone: A2Mr alpha-2, Mab antibody-; RPE Alternative name 3 CD91, Clone: A2Mr alpha-2, Mab antibody-; RPE
Bovine alpha 2 macroglobulin antibody Catalog: GWB-Q00626 | Size: 1 vial | Price: €564.33 Supplier: genways

Storage temperature store cold Expiry date 1 y Category research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Alpha 2 macroglobulin polyclonal igy antibody Catalog: GWB-20008F | Size: Ask | Price: Ask Supplier: genways bulk

Available sizes 0.05mg:275,1mg:3850 Old catalog number 15-288-20008F Store store in freezer for long therm or fridge for short time storage
uid :
2

name :
A2M

description :
alpha-2-macroglobulin

chromosome :
12

geneticsource :
genomic

maplocation :
12p13.31

otheraliases :
A2MD, CPAMD5, FWP007, S863-7

otherdesignations :
alpha-2-macroglobulin|C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|alpha-2-M

nomenclaturesymbol :
A2M

nomenclaturename :
alpha-2-macroglobulin

nomenclaturestatus :
Official

geneweight :
27007

chrsort :
12

chrstart :
9067707

annotationrelease: 109
assemblyaccver: GCF_000001405.38
chraccver: NC_000012.12
chrstart: 9116228
chrstop: 9067707
annotationrelease: 108
assemblyaccver: GCF_000001405.33
chraccver: NC_000012.12
chrstart: 9115961
chrstop: 9067707
annotationrelease: 108
assemblyaccver: GCF_000306695.2
chraccver: NC_018923.2
chrstart: 9237531
chrstop: 9189283
annotationrelease: 107
assemblyaccver: GCF_000001405.28
chraccver: NC_000012.12
chrstart: 9115961
chrstop: 9067707
annotationrelease: 107
assemblyaccver: GCF_000306695.2
chraccver: NC_018923.2
chrstart: 9237531
chrstop: 9189283
annotationrelease: 106
assemblyaccver: GCF_000001405.26
chraccver: NC_000012.12
chrstart: 9115961
chrstop: 9067707
annotationrelease: 106
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 106
assemblyaccver: GCF_000306695.2
chraccver: NC_018923.2
chrstart: 9237531
chrstop: 9189283
annotationrelease: 105
assemblyaccver: GCF_000001405.25
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 105
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 105
assemblyaccver: GCF_000306695.2
chraccver: NC_018923.2
chrstart: 9237531
chrstop: 9189283
annotationrelease: 104
assemblyaccver: GCF_000001405.22
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 104
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 104
assemblyaccver: GCF_000306695.1
chraccver: NC_018923.1
chrstart: 9147513
chrstop: 9099265
annotationrelease: 103
assemblyaccver: GCF_000001405.21
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 103
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 37.3
assemblyaccver: GCF_000001405.17
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 37.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 37.2
assemblyaccver: GCF_000001405.14
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 37.2
assemblyaccver: GCF_000002115.2
chraccver: AC_000055.1
chrstart: 10805675
chrstop: 10757429
annotationrelease: 37.2
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 37.1
assemblyaccver: GCF_000001405.13
chraccver: NC_000012.11
chrstart: 9268557
chrstop: 9220303
annotationrelease: 37.1
assemblyaccver: GCF_000002115.2
chraccver: AC_000055.1
chrstart: 10805675
chrstop: 10757429
annotationrelease: 37.1
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836
annotationrelease: 36.3
assemblyaccver: GCF_000001405.12
chraccver: NC_000012.10
chrstart: 9159824
chrstop: 9111570
annotationrelease: 36.3
assemblyaccver: GCF_000002115.2
chraccver: AC_000055.1
chrstart: 10805675
chrstop: 10757429
annotationrelease: 36.3
assemblyaccver: GCF_000002125.1
chraccver: AC_000144.1
chrstart: 9049087
chrstop: 9000836